Clinical Research
The Science Behind Immuno Armour
Immuno Armour™ is not built on marketing claims — it’s built on science. Every key ingredient in our formulas has been selected based on peer-reviewed clinical research, randomised controlled trials, and published meta-analyses from leading academic and medical institutions around the world.
Below you’ll find 19 published studies covering all five core Immuno Armour ingredients. This is the evidence base that gives us — and you — the confidence to call Immuno Armour the King of Immune Supplements.
Bacillus subtilis
Nature’s toughest probiotic warrior — clinically studied for immune stimulation, gut health, and human safety.
Study 01 Bacillus subtilis CU1 — Immune Stimulation in the Elderly
Randomised, Double-Blind, Placebo-Controlled Trial | Immunity & Ageing | Lefevre et al. | 2015
Consumption of Bacillus subtilis CU1 produced a 45% increase in salivary IgA relative to the placebo group, along with increased serum IFN-gamma levels — indicating meaningful immune stimulation in a senior population during the common infectious disease period.
→ View Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669646/
Study 02 Bacillus subtilis CU1 — Safety Assessment for Human Use
Clinical Safety Study | ScienceDirect | 2016
Bacillus subtilis CU1 was safely consumed at 2 × 10⁹ spores per day across all clinical subjects, with no undesirable physiological effects on liver and kidney function, blood counts, hemodynamic parameters, or vital signs — confirming its safety profile for use in food and supplement preparations.
→ View Study: https://www.sciencedirect.com/science/article/pii/S0273230016303452
Study 03 Bacillus subtilis DE111 — Gastrointestinal & Immunomodulatory Effects
Randomised Controlled Trial | MDPI International Journal of Molecular Sciences | Colorado State University | 2021
A clinical study of Bacillus subtilis DE111 in 46 healthy adults examined gut microbiota profiles, immune cell populations, and inflammatory markers. Researchers observed an increase in anti-inflammatory immune cell populations in response to ex vivo stimulation — supporting the immunomodulatory potential of this spore-forming probiotic strain.
→ View Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957723/
Saccharomyces cerevisiae
The fermented yeast at the heart of Immuno Armour — clinically studied across adults, non-vaccinated individuals, and children.
Study 04 EpiCor (Dried Yeast Fermentate) — Cold & Flu Symptoms in Adults
12-Week Randomised, Double-Blind, Placebo-Controlled Trial | PubMed | 2008
In a 12-week randomised, double-blind, placebo-controlled trial of 116 participants, daily supplementation with 500mg of EpiCor (dried Saccharomyces cerevisiae fermentate) was compared to placebo to assess the incidence and duration of cold and flu-like symptoms in healthy adults vaccinated for seasonal influenza.
→ View Study: https://pubmed.ncbi.nlm.nih.gov/18335698/
Study 05 EpiCor — Cold & Flu Symptoms in Non-Vaccinated Individuals
12-Week Randomised, Double-Blind, Placebo-Controlled Trial | PMC | 2019
A 12-week randomised, double-blind, placebo-controlled trial of 116 non-vaccinated subjects found that once-daily supplementation with 500mg of dried modified Saccharomyces cerevisiae oral fermentate (EpiCor) reduced the incidence and duration of cold and flu-like symptoms.
→ View Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498863/
Study 06 EpiCor — Cold & Flu Symptoms in Children (Ages 4–12)
Randomised Controlled Trial | Pediatric Research / Nature | 2024
256 children aged 4–12 years attending school or daycare were randomised to either EpiCor or placebo for 84 days during the 2022–2023 flu season. EpiCor postbiotic had previously been demonstrated to improve immune function in adults — this trial extended that investigation to the paediatric population.
→ View Study: https://www.nature.com/articles/s41390-024-03331-z
Study 07 Yeast Beta-1,3/1,6 Glucan — Upper Respiratory Tract Infection in Older Adults
Double-Blind, Placebo-Controlled Trial | ScienceDirect | 2017
A double-blind, randomised, placebo-controlled trial of Wellmune (a beta-1,3/1,6 glucan derived from the cell wall of Saccharomyces cerevisiae) was conducted over 90 days in community-dwelling adults aged 50–70 years, assessing its impact on upper respiratory tract infections and innate immune function.
→ View Study: https://www.sciencedirect.com/science/article/abs/pii/S0899900717300539
Study 08 Yeast Beta-Glucan — Antibody Response to Influenza Vaccination
Double-Blind, Randomised, Placebo-Controlled Pilot Trial | Taylor & Francis | 2025
90 adults were recruited across two vaccination seasons and randomised to receive 500mg of yeast beta-glucan or placebo daily, assessing the potential adjuvant effect of beta-glucan supplementation on antibody titer response to influenza vaccination and its impact on cold and flu symptoms.
→ View Study: https://www.tandfonline.com/doi/full/10.1080/19390211.2025.2539876
Vitamin C
One of the most extensively studied immune nutrients in the world — clinically proven to reduce the severity and duration of the common cold.
Study 09 Vitamin C Reduces Severity of Common Colds
Meta-Analysis of 10 Placebo-Controlled RCTs | BMC Public Health | Hemilä et al. | 2023
Across 15 comparisons from 10 randomised, double-blind trials, vitamin C supplementation at a minimum of 1g per day significantly decreased the severity of the common cold by 15% compared to placebo (95% CI 9–21%).
→ View Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712193/
Study 10 Vitamin C as Supplementary Therapy for the Common Cold
Meta-Analysis of 10 RCTs | BioMed Research International | Ran et al. | 2020
A meta-analysis of 10 randomised controlled trials found that vitamin C supplementation produced significantly better outcomes than antiviral therapy alone — improving total efficacy, time to symptom amelioration, and time to healing in common cold patients.
→ View Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569434/
Vitamin D3
Essential for immune and respiratory health — backed by some of the largest vitamin and immune trials ever conducted.
Study 11 Vitamin D3 — Upper Respiratory Tract Infections (VIDARIS Trial)
18-Month Randomised Controlled Trial | JAMA | 322 Healthy Adults | 2012
An 18-month randomised controlled trial of 322 healthy adults in New Zealand assessed the effect of vitamin D3 supplementation on the incidence and severity of upper respiratory tract infections — providing foundational evidence on its role in respiratory immune defence.
→ View Study: https://jamanetwork.com/journals/jama/fullarticle/1367547
Study 12 Vitamin D Supplementation to Prevent Acute Respiratory Infections
Systematic Review & Meta-Analysis of 46 RCTs | The Lancet Diabetes & Endocrinology | 2021
An updated meta-analysis building on a 2017 analysis of 25 RCTs confirmed that vitamin D supplementation has a protective effect against acute respiratory infections — representing one of the most comprehensive reviews of vitamin D and respiratory immune health to date.
→ View Study: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00051-6/fulltext
Study 13 Vitamin D3 — Prevention of Acute Respiratory Infection in Older Adults
Double-Blind Randomised Controlled Phase II Trial | PMC | 2017
A double-blind, randomised, controlled phase II trial of vitamin D3 supplementation over 12 months found that high-dose vitamin D3 reduced the incidence of acute respiratory infections in older adults, with vitamin D identified as playing an important role in innate immunity.
→ View Study: https://pmc.ncbi.nlm.nih.gov/articles/PMC5357189/
Zinc
A critical trace mineral for immune performance — with evidence spanning adults, children, and acute respiratory illness.
Study 14 Zinc Supplementation & Immune Factors in Adults
Systematic Review & Meta-Analysis of 35 RCTs | Critical Reviews in Food Science & Nutrition | 1,995 Participants | 2022
A comprehensive meta-analysis of 35 randomised controlled trials comprising 1,995 participants examined the effect of zinc supplementation on immune factors in adults — confirming zinc’s broad immunomodulatory role across multiple markers of immune response.
→ View Study: https://www.tandfonline.com/doi/abs/10.1080/10408398.2020.1862048
Study 15 Zinc Promotes Th1 Immune Response in Children with Pneumonia
Randomised Controlled Clinical Trial | Frontiers in Pediatrics | 103 Children | 2019
In a randomised controlled trial of 103 children aged 1 month to 5 years with pneumonia, zinc supplementation significantly improved clinical status, respiratory rate, and oxygen saturation in fewer hours compared to placebo — and was associated with a meaningful Th1 immune response.
→ View Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874056/
Study 16 Zinc for Prevention and Treatment of the Common Cold
Cochrane Systematic Review | Cochrane Library | 2024
The 2024 Cochrane review examined zinc for the prevention and treatment of the common cold across multiple randomised trials, drawing on a substantial body of evidence linking zinc status to immune function and susceptibility to respiratory infections.
→ View Study: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD014914.pub2/references
Selenium
A powerful antioxidant trace element — clinically studied for its role in reducing inflammation and supporting immune cell function.
Study 17 Selenium & Immune Function — Systematic Review & Meta-Analysis
Systematic Review & Meta-Analysis of RCTs | American Journal of Clinical Nutrition | 2023
A systematic review and meta-analysis of experimental human studies examined the effect of selenium supplementation on immune function across multiple randomised controlled trials — measuring plasma selenium concentrations and immune outcomes before and after intervention.
→ View Study: https://ajcn.nutrition.org/article/S0002-9165(22)10528-9/fulltext
Study 18 Selenium Supplementation Reduces Inflammatory Markers (CRP)
Systematic Review & Meta-Analysis of RCTs | ScienceDirect | 2020
A meta-analysis of randomised controlled clinical trials found that selenium supplementation significantly reduced serum CRP levels — particularly in patients with elevated baseline inflammation — supporting selenium’s role as an antioxidant and anti-inflammatory micronutrient.
→ View Study: https://www.sciencedirect.com/science/article/abs/pii/S2451847620300026
Study 19 The Immunomodulatory Effects of Selenium — Comprehensive Review
Review | Nutrients Journal | MDPI | 2024
A 2024 review of selenium’s immunomodulatory mechanisms found that randomised double-blind controlled trials using 200µg of selenium per day for 12 weeks demonstrated meaningful effects on immune markers — with selenium’s antioxidant activity helping control inflammatory processes through the scavenging of reactive oxygen and nitrogen species.
→ View Study: https://www.mdpi.com/2072-6643/16/19/3324
Built on Evidence. Formulated for Life.
Every ingredient in Immuno Armour™ has been selected with one standard in mind — does the clinical evidence support it? The answer, across 19 peer-reviewed studies, is a resounding yes.
From spore-forming probiotics that survive digestion, to beta-glucans that prime innate immunity, to vitamins and minerals with decades of clinical data behind them — Immuno Armour is the immune supplement that earns its place in your home.